CRO            

Xenoblis; AvogadroOroxcell Stabiligen;  Absorption Systems; ATC;   GenPharmTox ,; Corealis

 

 

    Biopredic Parc d'affaires de la Breteche Bat B1 35760 Saint Gregoire

           Phone: 33-2 99 23 77 77

           Fax :    33-2 23 25 29 74

Françoise Brée: francoise.bree@xenoblis.com

 

        

DESCRIPTIVE DRUG METABOLISM

Human, Laboratory animals, Farm animals 

Assay systems (S9, Microsomes, Hepatocytes, Isolated perfused liver)

Interspecies comparison

Metabolite production (mg scale)

ENZYMOLOGY DRUG-DRUG INTERACTIONS

Enzymatic parameters

Phenotyping, Inhibition & Induction CYP, UDPGT

BINDING TO PLASMA PROTEINS

In vitro & ex vivo

Methods ( Equilibrium dialysis, ultracentrifugation, Partitioning: red blood cells

Binding parameters

Simulation of the drug distribution in blood

PASSAGE AND TRANSPORT

Organ : Isolated perfused liver, lung & intestine. (Soon)

 Tissue:  Skin: absorption/penetration; Intestine: Everted gut segments,  

Cell systems : Blood Brain Barrier;  HepaRG  (New), Genomembrane ®  Transfected cell-line vesicles

Pumps, Influx and Efflux

HEPATO-TOXICITY 

Glutathione depletion in hepatocytes

Covalent binding in microsomes

Enzymes and glycogen release in the isolated perfused liver and hepatocytes 

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AVOGADRO

Parc de Génibrat

31470 FONTENILLES cedex

France

Phone l: 33-5-62 14 73 14

Fax      : 33-5 62 14 73 10

 

email avogadro@avogadro.fr

internet www.avogadro-lab.com

 

Avogadro is an independent contract research company specializing in pharmaceutical analysis, bioanalytical chemistry, drug metabolism and in-life phase studies. It was established in 1998 and provides services to the human and veterinary pharmaceutical sectors. It is based near Toulouse, France.

Avogadro offers a flexible, experienced and highly specialized team (25 Scientists) that work closely alongside client companies to provide effective development for new molecules or support for existing products.

Specific services offered include development and validation of analytical methods, pharmacokinetics, metabolism, ADME and residue studies in all laboratory and food-producing species.

The motivated, multi-disciplinary team is based in facilities (1500 m²) that offer both new and extensive research laboratories together with excellent animal accommodation.Avogadro is dedicated to providing clients with studies conducted to the highest scientific and regulatory standards (full GLP compliance), in a timely fashion and on bud

From now on, you can get in touch with your contact person in Avogadro by e-mail using the following address format:

 
          first-name.surname@avogadro.fr      (for example:  marie.curie@avogadro.fr)
 
You can also contact us at:
 

          avogadro@avogadro.fr

          administration@avogadro.fr

          direction@avogadro.fr

          informatique@avogadro.fr

          qualite@avogadro.fr

 

You can still contact us for a few months at: 

           avogadro@wanadoo.fr 

          Looking foward to hearing from you.

         Thank you for your cooperation.

 

 

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OROXCELL SAS     Created: 2004   Headcount: 24 

THE ORGANIZATION 

Executive Management

 

·          Jean PACHOT, President & C.S.O.

·          Christophe DINI, Vice President and Chemical & Physical Sciences Director

·          Jacques BITON.Vice President and Life Sciences Director. 

Funding history

 

·       OROXCELL is a successful French Spin-Off of Sanofi Aventis founded by three experienced senior scientists who jointly own 100 % of that independent and privately-owned CRO.

·       OROXCELL has been recognized as an innovative new company by the distinguished ANVAR 2004 award.

The French Senate has named Jean PACHOT, the CEO and CSO to be one of the most innovative young entrepreneurs of 2005.

·       OROXCELL received the Label of “Jeune Entreprise Innovante” (“Innovative New Company”) from the French Ministry of Research and is a member of the progressive group “Ile de France Meditech Santé”.

 

A year after its creation, OROXCELL employs 24 staff

More than 30 contracts have been signed with a range of Pharmaceutical and Life Sciences companies.

Organization profile

 

OROXCELL is a leading French CRO focusing on the bioavailability of compounds issuing from life sciences.

The company has extensive expertise in both innovative formulations for oral absorption, and new in vitro technologies to evaluate ADME parameters, physico-chemistry, bioanalysis and molecular pharmaceutics.

OROXCELL offers, through patented formulation technologies, real opportunities to add value to life sciences products.

Founded mid 2004, OROXCELL, award-winning for its innovation, is a unique “one-stop shopping” platform which covers a broad spectrum of technologies allowing its partners to reach their scientific and economic goals readily.

1. PRE-CLINICAL CROS

CONTACT:

o         JEAN PACHOT /// jean.pachot@oroxcell.com

ADDRESS :

o          PARC BIOCITECH - 102, ROUTE DE NOISY, 93230 ROMAINVILLE, FR

 

ACTIVITIES 

Technology overview / Expertise areas / Trade marks

 

Caco-2, P-gp interaction, metabolic stability (S9, microsomes, hepatocytes), Cyp inhibition, induction, Log P, Log D, pKa, LCMS, LCMSMS, LCUV, radioactivity, PK in rodents, tissue distribution.

Products and services 

• ADME Screening and profiling,

• Pre-clinical PK studies,

• Formulation, bioanalysis,

• Physico-chemical determination,

• Stability testing.

Partners 

Anaconda, Cellial, Euroscreen, Galderma, Guerbet, IPSEN,

L’Oréal, Sanofi aventis, Servier, Institut de Recherche Pierre Fabre,

Urogene, Theraptosis.

Aeras of potential collaboration / Opportunities 

Lead optimization, drug candidate selection, formulation, oral absorption

improvement, ADME and Physico-chemistry determination, rescue projects

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SIEST Jean-Pascal 
STABILIGEN S.A.
Technopôle de Nancy-Brabois
3 route de l'Aviation - B.P. 70
54603 VILLERS-LES-NANCY cedex
Téléphone : +33 (0)3 83 44 51 44
Télécopie : +33 (0)3 83 44 51 40
E-mail : stabiligen@stabiligen.com
Site internet : www.stabiligen.com

 

Has been created in 1985 and is specialized in induction and inhibition enzymatic studies linked to the cytochrome P450 3A4.

STABILIGEN has developed an URINARY 6ß-HYDROXYCORTISOL ASSAY. This in vivo human test allows the measurement of one liver enzyme activity responsible for drug metabolism. As none of the enzyme activities are directly mesurable in biological fluids, indirect tests based on the measurement of endogenous and exogenous substrates have been developed.
The cytochrome P450 3A4 (CYP 3A4) is responsible for the conversion of cortisol into 6ß-hydroxycortisol. The urinary excretion of 6ß-hydroxycortisol thus reflects the liver activity of CYP 3A4.
A competitive ELISA method is available in ready-to-use kit form for the measurement of 6ß-hydroxycortisol :
CHARACTERISTICS OF THE  6ß-HYDROXYCORTISOL KIT : an immunoenzymatic test for the assay of 6ß-hydroxycortisol in urine
* ELISA : - plate of 96 wells
- polyclonal antibody
- urinary measurements without any extraction
- colorimetric assay using a peroxidase conjugate
* High Specificity
* Low Detection Limit (50 pg)
* On request, STABILIGEN can help you by performing the assay of 6ß-hydroxycortisol (of cortisol      and creatinine too) on the biological fluids you send."

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HIDALGO Ismael ; HERON Alain      

                                      

440 Creamery Way, Suite 300
Exton, Pa 19341-2554
Ph: 610-280-9619 direct
Ph: 610-280-7300 general
Fax: 610-280-9667
Email: Hidalgo@Absorption.com

          Heron@Absorption.com
Web : http://www.absorption.com

Absorption Systems is a highly specialized leading Contract Research Organization, focusing on the rapid assessment of biopharmaceutical properties of new and existing chemical compounds.  Our clients include Big Pharmaceutical, small biotech and drug discovery companies. Using in-vitro, in-vivo and ex-vivo models, we categorize and document your most promising compounds with unmatched efficiency, accuracy and quality control. With our complete range of services, we can assist you in shortening the drug discovery and development process.

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KREMERS Pierre PhD        

ATC   :  Advanced Technology Corporation

Institut de Pathologie-Bât B23

B-4000 SART TILMAN (LIEGE)

Tel  : 32 (0) 4/366 24 71

Fax: 32 (0) 4/366 24 81

 

pkremers@chu.ulg.ac.be         http://www.atc-pharma.com

 

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  Prof. Dr. Johannes Doehmer        

CEO GenPharmTox BioTech AG

  Fraunhoferstr. 9
  D-82152 Martinsried/Planegg

  Phone: +49-(0)89-89 555 9 - 0
  E-mail: johannes.doehmer@genpharmtox.de

GenPharmTox BioTech AG provides first class service on metabolism studies of drugs and chemicals and metabolism related toxicity based on its unique V79 Cell Battery™ which is a collection of V79 cell cultures expressing single human, rat, and mouse cytochromes P450 and a variety of the so-called phase II enzymes.

 With this tool at hand we offer:

metabolic stability studies

inhibition studies

drug interaction studies

metabolite profiling and identification

ranking programme of your lead compounds

Our studies have a proven record of high data quality and high predictivity for man delivered in time.

Our partnership with RCC and Cytonet allows us to design solution packages for you from early preclinical development up to clinical studies.

 For further details please check our website http://www.genpharmtox.de or send an e-mail to info@genpharmtox.de and ask for our service catalogue including pricing.

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141, avenue du Président-Kennedy, suite SB-6520

Montréal, Québec 

Canada

Pour plus d’information Tél. : +1-514-987-0401

                                  Email : info@corealispharma.com

Corealis Pharma est une firme de prestation de services en développement galénique de

formes pharmaceutiques solides diverses (i.e. comprimés et capsules) ainsi que la

fabrication et le conditionnement de matériels cliniques de phase I et II.

Corealis offre le développement complet ou certaines étapes très spécifiques telles que :

§ Caractérisation du principe actif et l’aide à la sélection des sels (e.g. formes

cristallines, taille des particules, solvates, hygroscopicité, stabilité);

§ Pré-formulation (compatibilité drogue-drogue ou drogue-excipient, compressibilité, densité, écoulement);

§ Développement galénique

   o compression directe,

   o granulation humide (mélangeur high shear et par lit d’air fluidisé),

   o séchage (four et par lit d’air fluidisé)

   o granulation sèche (roller compactor),

   o séchage par atomisation (aqueux/solvant),

  o extrusion/sphéronisation,

  o fabrication de comprimés (presses manuelles une station et rotative multistation)

  o encapsulation de gélules moles et rigides (poudre sèche, granules, fusion à chaud, suspension et solution);

§ Développement des méthodes analytique (e.g. principe actif et substances reliées,dissolution);

§ Transfer de méthode analytique;

§ Entreposage et tests de stabilité;

§ Transfer et mise à l’échelle de formulations et de procédés;

§ Fabrication de matériels clinique de phase I et II selon les normes BPF;

§ Conditionnement de matériels clinique (e.g. blister, embouteillage, préparation de

kits patient, conditionnement à simple, double ou triple insu);

§ Gestion et entreposage cBPF du matériel d’essais clinique.

Les experts de Corealis ont accès à des installations et de l’équipement R et D moderne et

des installations de fabrication et d’emballage cBPF qui leurs permettent de compléter

avec succès les mandats les plus complexes et stimulants.

Pour plus d’information sur Corealis Pharma, je vous invite à visiter notre site internet

http://www.corealispharma.com/

 

 

 

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