Update

Update: Grapefruit Juice-Drug Interactions

Grapefruit juice-drug interaction studies as a method to assess the extent of intestinal availability: utility and limitations.

Gertz M, Davis JD, Harrison A, Houston JB, Galetin A.

Curr Drug Metab. 2008 Oct;9(8):785-95. Review.

PMID: 18855612 [PubMed - indexed for MEDLINE]

Different roles of pummelo furanocoumarin and cytochrome P450 3A5*3 polymorphism in the fate and action of felodipine.

Guo LQ, Chen QY, Wang X, Liu YX, Chu XM, Cao XM, Li JH, Yamazoe Y.

Curr Drug Metab. 2007 Aug;8(6):623-30.

PMID: 17691921 [PubMed - indexed for MEDLINE]

Grapefruit juice-drug interactions: Grapefruit juice and its components inhibit P-glycoprotein (ABCB1) mediated transport of talinolol in Caco-2 cells.

de Castro WV, Mertens-Talcott S, Derendorf H, Butterweck V.

J Pharm Sci. 2007 Oct;96(10):2808-17.

PMID: 17542018 [PubMed - indexed for MEDLINE]

Variation of flavonoids and furanocoumarins in grapefruit juices: a potential source of variability in grapefruit juice-drug interaction studies.

De Castro WV, Mertens-Talcott S, Rubner A, Butterweck V, Derendorf H.

J Agric Food Chem. 2006 Jan 11;54(1):249-55.

PMID: 16390207 [PubMed - indexed for MEDLINE]

Grape fruit juice-drug interactions.

Arayne MS, Sultana N, Bibi Z.

Pak J Pharm Sci. 2005 Oct;18(4):45-57. Review.

PMID: 16380358 [PubMed - indexed for MEDLINE]

Undesirable effects of citrus juice on the pharmacokinetics of drugs: focus on recent studies.

Saito M, Hirata-Koizumi M, Matsumoto M, Urano T, Hasegawa R.

Drug Saf. 2005;28(8):677-94. Review.

PMID: 16048354 [PubMed - indexed for MEDLINE]

Bergamottin contribution to the grapefruit juice-felodipine interaction and disposition in humans.

Goosen TC, Cillié D, Bailey DG, Yu C, He K, Hollenberg PF, Woster PM, Cohen L, Williams JA, Rheeders M, Dijkstra HP.

Clin Pharmacol Ther. 2004 Dec;76(6):607-17.

PMID: 15592332 [PubMed - indexed for MEDLINE]

Two major grapefruit juice components differ in time to onset of intestinal CYP3A4 inhibition.

Paine MF, Criss AB, Watkins PB.

J Pharmacol Exp Ther. 2005 Mar;312(3):1151-60. Epub 2004 Oct 14.

PMID: 15485894 [PubMed - indexed for MEDLINE]

Two major grapefruit juice components differ in intestinal CYP3A4 inhibition kinetic and binding properties.

Paine MF, Criss AB, Watkins PB.

Drug Metab Dispos. 2004 Oct;32(10):1146-53. Epub 2004 Jul 21.

PMID: 15269184 [PubMed - indexed for MEDLINE]

10:

Inhibition of cytochrome P450 by furanocoumarins in grapefruit juice and herbal medicines.

Guo LQ, Yamazoe Y.

Acta Pharmacol Sin. 2004 Feb;25(2):129-36. Review.

PMID: 14769198 [PubMed - indexed for MEDLINE]

11:

Oral midazolam-grapefruit juice drug interaction.

Goho C.

Pediatr Dent. 2001 Jul-Aug;23(4):365-6.

PMID: 11572503 [PubMed - indexed for MEDLINE]

12:

Inhibition of P-glycoprotein transport function by grapefruit juice psoralen.

Wang EJ, Casciano CN, Clement RP, Johnson WW.

Pharm Res. 2001 Apr;18(4):432-8.

PMID: 11451028 [PubMed - indexed for MEDLINE]

13:

Grapefruit juice-drug interactions.

Bailey DG, Malcolm J, Arnold O, Spence JD.

Br J Clin Pharmacol. 1998 Aug;46(2):101-10. Review.

PMID: 9723817 [PubMed - indexed for MEDLINE]

14:

The fate of naringin in humans: a key to grapefruit juice-drug interactions?

Fuhr U, Kummert AL.

Clin Pharmacol Ther. 1995 Oct;58(4):365-73.

PMID: 7586927 [PubMed - indexed for MEDLINE]

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